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Since MK-677 is not authorized for human application, there is a lack of published specific contraindications

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The most common side effects are mild: slight water retention, flushing, or injection site reactions

Results Mitochondrial respiratory function persists under cystine deprivation To determine the influence of cysteine deprivation on mitochondrial metabolism, we restricted a panel of NSCLC cells of extracellular cystine

383 However, Lesinurad is a relatively new pharmaceutical agent, currently lacks data regarding its potential impact on cardiovascular and renal outcomes